Prescribing

Valproate

Valproate medication can be very effective in treating epilepsy (seizures or fits) or bipolar disorder, and other health problems. It is often used where other medication has not been effective.

Valproate can affect the way an unborn baby’s body and brain grows. There can be a 30-40% chance of having a problem with how the baby’s brain develops during pregnancy. This might mean they have a learning disability or autism or cannot pay attention or sit still (ADHD).

Women and people who could become pregnant aged under 55 will be invited to an annual medication review with their specialist. They will discuss the medication they are taking. They will also discuss the chance of becoming pregnant or fathering a baby.

There is advice that valproate should be avoided where possible when planning a pregnancy. However, it should not be stopped without careful supervision by a specialist. Changing from valproate to a medication that might not work as well, or changing it quickly, could make seizures or health problems worse. This may include more serious illness or death, including sudden unexpected death in epilepsy (SUDEP), or suicide for people with bipolar disorder.

Discussions around taking valproate should be person-centred, aiming to reduce the risk to both the person taking valproate and to a potential future baby. At all times the discussion should respect the wishes and choices of people and/or their carers.

For this information in other languages, click the link:

https://www.southeastclinicalnetworks.nhs.uk/our-networks/valproate/